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Sens-it-iv Scientific Publications

2010

  • Martin SF, Cavani A, Maggi E, Thierse HJ, Richter A, Sallusto F: T-cell priming and amplification: Exploiting key events in contact sensitization.* */ALTEX Congress Proceedings/: VII World Congress on Alternatives & Animal Use in the Life Sciences.* */ALTEX /2010/,/ 27: 309-311/.
  • Schmidt, M., B. Raghavan, V. Müller, T. Vogl,G. Fejer, S. Tchaptchet, S. Keck, C. Kalis, P. Nielsen, C. Galanos, J. Roth, A. Skerra, S.F. Martin, M.A. Freudenberg,^ M. Goebeler. 2010. A crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. /Nat. Immunol./ 11:815-819. doi:10.1038/ni.1919.
  • Martin, S.F., P.R. Esser, S. Schmucker, L. Dietz, D.J. Naisbitt, B.K. Park, M. Vocanson,  J.-F. Nicolas, M. Keller, W.J. Pichler, M. Peiser, A. Luch, R. Wanner, E. Maggi, A. Cavani, T. Rustemeyer, A. Richter, H.-J. Thierse, F. Sallusto. 2010. T cell recognition of chemicals, protein allergens and drugs: towards the development of /in vitro/ assays. /Cell. Mol. Life Sci//. /Advance online publication 18 August 2010./ /doi: 10.1007/s00018-010-0495-3.
  • Martin S.F. 2010.* *The role of the innate immune system in allergic contact dermatitis. /Allergologie/ 33:66-70. Englische Version online.
  • Schmidt, M., B. Raghavan, V. Müller, T. Vogl,G. Fejer, S. Tchaptchet, S. Keck, C. Kalis, P. Nielsen, C. Galanos, J. Roth, A. Skerra, S.F. Martin, M.A. Freudenberg,^ M. Goebeler. 2010. A crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. /Nat. Immunol./ advance online publication, 15 August 2010. doi: 10.1038/ni.1919.
  • Martin S.F. *2010.* *The role of the innate immune system in allergic contact dermatitis. Allergologie 33:66-70. English version online.
  • Dietz, L., P.R. Esser, S. Schmucker, I. Goette, A. Richter, M. Schnoelzer, *S.F. Martin*, H.J. Thierse. 2010. Tracking human contact allergens: >From mass spectrometric validated chemical-peptide interactions to chemical-specific naïve human T cell priming. */Toxicol. Sci./* 116: ToxSci Advance Access published on July 14, 2010. doi:10.1093/toxsci/kfq209
  • Lass, C., I. Merfort, *S.F. Martin*. 2010. In vitro and in vivo analysis of pro-and anti-inflammatory effects of weak and strong contact allergens. */Exp. Dermatol/.*, advance online publication, 5 August 2010 (DOI:10.1111/j.1600-0625.2010.01136.x).
  • Mitjans M, Galbiati V, Lucchi L, Viviani B, Marinovich M, Galli CL, Corsini E. Use of IL-8 release and p38 MAPK activation in THP-1 cells to identify allergens and to assess their potency in vitro. Toxicol. In Vitro (2010), in press doi:10.1016/j.tiv.2010.06.001
  • Switalla S, Knebel J, Ritter D, Krug N, Braun A, Sewald K. Effects of acute in vitro exposure of murine precision-cut lung slices to gaseous compounds nitrogen dioxide and ozone in an air-liquid interface (ALI) culture. Epub 2010 Apr 13. Toxicol Lett. 2010 Jul 1;196(2):117-24.
  • Switalla S, Lauenstein L, Prenzler F, Knothe S, Förster C, Fieguth HG, Pfennig O, Schaumann F, Martin C, Guzman CA, Ebensen T, Müller M, Hohlfeld JM, Krug N, Braun A, Sewald K. Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices. Toxicol Appl Pharmacol. 2010 Apr 29. [Epub ahead of print]

2009

  • Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. Type 17 T helper cells-origins, features and possible roles in rheumatic disease. Nat Rev Rheumatol. 2009, 5: 325-31.
  • Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. Human Th17 cells: are they different from murine Th17 cells? Eur J Immunol. 2009, 39: 637-40.
  • Corsini E, Mitjans M, Galbiati V, Lucchi L, Galli CL, Marinovich M. Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens.Toxicol in Vitro. 2009, 23: 789-96.
  • Corsini E, Roggen EL.  Immunotoxicology: opportunities for non-animal test development. Altern Lab Anim. 2009 37(4):387-97.
  • Dietz L, Bosque A, Pankert P, Ohnesorge S, Merz P, Anel A, Schnoelzer S, Thierse HJ. Quantitative DY- maleimide-based proteomic 2-DE-labeling strategies using human skin proteins. Proteomics 2009, 9: 4298- 4308.
  • dos Santos, GG. Reinders J, Ouwehand K, Rustemeyer T, Scheper RJ, Gibbs S. Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound. Toxicol Appl Pharmacol 2009, 236: 372-82
  • Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A. Interleukin 17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response. J Allergy Clin Immunol 2009, 123: 59-66.
  • Fleischel O, Giménez-Arnau E, Lepoittevin JP. NMR studies on covalent modification of amino acids thiol and amino residues by monofunctional aryl 13C-isocyanates, models of skin and respiratory sensitizers. Transformation of thiocarbamates into urea adducts. Chem Res Toxicol 2009, 22: 1106-1115.
  • Freudenberg, MA, Esser PR, Jakob T, Galanos C, Martin SF. Innate immune responses in allergic contact dermatitis – analogy with infections. G Ital Dermatol Venereol (Italian J Dermatol) 2009, 144: 173-185.
  • Heise R, Skazik C, Rodriguez F, Stanzel S, Marquardt Y, Joussen S, Wendel AF, Wosnitza M, Merk HF, Baron JM. Active Transport of Contact Allergens and Steroid Hormones in Epidermal Keratinocytes is Mediated by Multidrug Resistance Related Proteins J Invest Dermatol 2009 Jul 9. [Epub ahead of print]
  • Larsson K, Lindstedt M, Lundberg K, Dexlin L, Wingren C, Korsgren M, Greiff L, Borrebaeck CA. CD4+ T cells have a key instructive role in educating dendritic cells in allergy. Intern Archives Allergy Immunol 2009, 149(1):1-15.
  • Megherbi R, Kiorpelidou E, Foster B, Farrell J, Rowe C, Naisbitt DJ, Goldring CE, Park BK. Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP1. Toxicol Appl Pharmacol 2009, 238: 120-32.
  • Ott H, Bergström MA, Heise R, Skazik C, Zwadlo-Klarwasser G, Merk HF, Baron JM, Karlberg AT. Cutaneous metabolic activation of carvoxime, a self-activating, skin-sensitizing prohapten Chem Res Toxicol. 2009, 22: 399-405
  • Nelissen I, Selderslaghs I, Van Den Heuvel R, Witters H, Verheyen GR, Schoeters G. MUTZ-3-derived dendritic cells as an in vitro alternative model to CD34+ progenitor-derived dendritic cells for testing of chemical sensitizers. Toxicol In Vitro (2009) 23(8):1477-81.
  • Ouwehand K, Spiekstra SW, Reinders J, Scheper RJ, de Gruijl TD, Gibbs S.Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells. Toxicol In Vitro. 2009 Oct 28. [Epub ahead of print]
  • Python F, Goebel C, Aeby P. Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde. Toxicol. Appl Pharmacol 2009, 293: 273-283.
  • Santarlasci V, Maggi L, Capone M, Frosali F, Querci V, De Palma R, Liotta F, Cosmi L, Maggi E, Romagnani S, Annunziato F. TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells. Eur J Immunol. 2009, 39: 207-15.
  • Spiekstra SW, Dos Santos GG, Scheper RJ, Gibbs S. Potential method to determine irritant potency in vitro - Comparison of two reconstructed epidermal culture models with different barrier competency. Toxicol In Vitro 2009, 23: 349-55.
  • Toebak MJ, Gibbs S, Bruynzeel DP, Scheper RJ, Rustemeyer T. Dendritic cells: biology of the skin. Contact Dermatitis 2009, 60: 2-20.
  • Vultaggio A, Nencini F, Fitch PM, Filì L, Maggi L, Fanti P, deVries A, Beccastrini E, Palandri F, Manuelli C, Bani D, Giudizi MG,*Guarna A, Annunziato F, Romagnani S, Maggi E, Howie SEM, Parronchi P. Modified (9-benzyl-2-butoxy-8-hydroxy) adenine redirects T helper(Th)2-mediated murine lung inflammation by triggering TLR7 J Immunol 2009, 182: 880–889.
  • Weltzien HU, Corsini E, Gibbs S, Lindstedt M, Borrebaeck C, Budde P, Schulz-Knappe P, Thierse HJ, Martin SF, Roggen EL. Safe Cosmetics Without Animal testing? Contributions of the EU Project Sens-it-iv. Journal für Verbraucherschutz und Lebensmittelsicherheit 2009, online ahead of print: doi 10.1007/s00003- 009-0510-5

2008

  • Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int Immunol. 2008, 20: 1361-8
  • Baron JM, Wiederholt T, Heise R, Merk HF, Bickers DR. Expression and function of cytochrome P450-dependent enzymes in human skin cells. Curr Med Chem 2008, 15: 2258-64.
  • Cavani A. T regulatory cells in contact hypersensitivity. Curr Opin Allergy Clin Immunol 2008, 8: 294- 298
  • Cosmi L, De Palma R, Santarlasci V, Maggi L, Capone M, Frosali F, Rodolico G, Querci V, Abbate G, Angeli R, Berrino L, Fambrini M, Caproni M, Tonelli F, Lazzeri E, Parronchi P, Liotta F, Maggi E, Romagnani S, Annunziato F. Human interleukin-17-producing cells originate from a CD161+ CD4+ T-cell precursor, J Exp Med 2008, 205: 1903-16.
  • Coulter EM, Jenkinson C, Wu Y, Farrell J, Foster B, Smith A, McGuire C, Pease C, Basketter D, King C, Friedmann PS, Pirmohamed M, Park BK, Naisbitt DJ. Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base. J Invest Dermatol. 2008, 128: 897-905.
  • Hagvall L, Baron JM, Börje A, Weidolf L, Merk H, Karlberg AT. Cytochrome P450-mediated activation of the fragrance compound geraniol forms potent contact allergens. Toxicol Appl Pharm 2008, 233: 308-13.
  • Henjakovic M, Martin C, Hoymann HG, Sewald K, Ressmeyer AR, Dassow C, Pohlmann G, Krug N, Uhlig S, Braun A. Ex vivo lung function measurements in precision-cut lung slices (PCLS) from chemical allergen- sensitized mice represent a suitable alternative to in vivo studies. Toxicological Sciences 2008,106: 444-53.
  • Henjakovic M, Sewald K, Switalla S, Kaiser D, Muller M, Veres TZ, Martin C, Uhlig S, Krug N, Braun A. Ex vivo testing of immune responses in precision-cut lung slices. Toxicol Appl Pharmacol 2008, 231: 68-76.
  • Lindstedt M. Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions. J Leukoc Biol 2008, 84: 143-51.
  • Liotta F, Frosali F, Querci V, Mantei A, Filì L, Maggi L, Mazzinghi B, Angeli R, Ronconi E, Santarlasci V, Biagioli T, Lasagni L, Ballerini C, Parronchi P, Scheffold A, Cosmi L, Maggi E, Romagnani S, Annunziato F. Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction. J Allergy Clin Immunol. 2008, 121: 1000-8.
  • Mitjans M, Viviani B, Lucchi L, Galli CL, Marinovich M, Corsini E. Role of p38 MAPK in the selective release of IL-8 induced by chemical allergens in naïve THP-1 cells. Toxicology in vitro 2008, 22: 386- 395
  • Santegoets S, Gibbs S, Kroeze K, van de Ven R, Scheper R, Borrebaeck C, de Gruijl T, Lindstedt M. Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions. J Leukoc Biol 2008, 84: 143-51.
  • Ouwehand K, Santegoets SJ, Bruynzeel DP, Scheper RJ, de Gruijl TD, Gibbs S. CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis. Eur J Immunol 2008, 38: 3050-9.
  • Santegoets SJ, Gibbs S, Kroeze K, van de Ven R, Scheper RJ, Borrebaeck CA, de Gruijl TD, Lindstedt M. Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions. J Leukocyte Biol 2008, 84: 143-51.
  • Skazik C, Heise R, Bostanci O, Paul N, Denecke B, Kiehl K, Merk HF, Zwadlo-Klarwasser G, Baron JM. Differential expression of influx and efflux transport proteins in human antigen presenting cells. Exp Dermatol 2008, 17: 739-747.
  • Thierse HJ, Helm H, Pankert P. Metalloproteomics in the Molecular Study of Cell Physiology and Disease. Meth Mol Biol 2008, 425: 139-147.

2007

  • Bergstrom MA, Ott H, Carlsson A, Neis M, Zwadlo-Klarwasser G, Jonsson CA, Merk HF, Karlberg AT and Baron JM. A skin-like cytochrome P450 cocktail activates prohaptens to contact allergenic metabolites. J Invest Dermatol 2007, 127: 1145-1153.
  • Cavani A, De Pità O, Girolomoni G. New aspects of the molecular basis of contact allergy. Curr Opin Allergy Clin Immunol 2007, 7: 404-408.
  • Coulter EM, Jenkinson C, Wu Y, Farrell J, Foster B, Smith A, McGuire C, Pease C, Basketter D, King C, Friedmann PS, Pirmohamed M,Park BK, Naisbitt DJ. Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski’s base. J Invest Dermatol, 2007, 128: 897-905.
  • Edele F, Esser PR, Lass C, Laszczyk MN, Oswald E, Strüh CM, Rensing-Ehl A, Martin SF. Innate and adaptive immune responses in allergic contact dermatitis and autoimmune skin diseases. Inflammation and Allergy ? Drug Targets 2007, 6: 236-244.
  • Kimber I, Agius R, Basketter DA, Corsini E, Cullinan P, Dearman RJ, Gimenez-Arnau E, Greenwell L, Hartung T, Kuper F, Maestrelli P, Roggen EL, Rovida C. Chemical respiratory allergy: opportunities for hazard identification and characterisation. The report and recommendations of ECVAM workshop 60. European Centre for the Validation of Alternative Methods. ATLA-Alternatives to Laboratory Animals 2007, 35: 243-65.
  • Maggi L, Santarlasci V, Liotta F, Frosali F, Angeli R, Cosmi L, Maggi E, Romagnani S, Annunziato F. Demonstration of circulating allergen-specific CD41CD25highFoxp31 T-regulatory cells in both nonatopic and atopic individuals. J Allergy Clin Immunol 2007, 120: 429-436.
  • Merk HF, Baron JM, Neis MM, Höller Obrigkeit D, Karlberg AT. Skin: Major target organ of allergic reactions to small molecular weight compounds. Toxicol Appl Pharm 2007, 224: 313-7.
  • Rovida C, Roggen EL. Management of an Integrated Project (Sens-it-iv) to develop in vitro tests to assess sensitisation, ATLA 2007, 35: 317–322.
  • Thierse, HJ, Helm H, Pink M, Weltzien HU. Novel Fluorescence Assay for Tracking Molecular and Cellular Allergen-Protein Interactions. J. Immunol. Meth. 2007, 328:14-20.